Howanitz N, Nordlund J L, Lerner A B, Bystryn J C
Arch Dermatol. 1981 Nov;117(11):705-8. doi: 10.1001/archderm.117.11.705.
The prevalence of antibodies to melanocytes was determined by an immunofluorescence complement fixation technique in 294 patients with vitiligo, other pigmentary disorders, and unrelated dermatoses. Antimelanocyte antibodies were present in the sera of five (29%) of 17 patients with chronic mucocutaneous candidiasis. Only two of the five patients with antibodies had vitiligo. No antibodies to melanocytes were found in the sera of 31 patients with common vitiligo or of 38 patients with vitiligo associated with autoimmune diseases or melanoma. Nor were antibodies to melanocytes found in 129 patients with other diseases of pigment-producing cells or in a control group of 79 patients with nonpigmentary dermatoses. These results suggest that complement fixing antibodies to melanocytes are associated wih chronic mucocutaneous candidiasis but are not involved in the pathogenesis of common vitiligo.
采用免疫荧光补体结合技术，对294例白癜风患者、其他色素沉着紊乱患者及无关皮肤病患者检测黑素细胞抗体的流行情况。17例慢性黏膜皮肤念珠菌病患者中，5例（29%）血清中存在抗黑素细胞抗体。这5例有抗体的患者中只有2例患有白癜风。31例普通白癜风患者、38例伴有自身免疫性疾病或黑素瘤的白癜风患者血清中均未发现抗黑素细胞抗体。129例其他色素生成细胞疾病患者以及79例非色素性皮肤病对照组患者血清中也未发现抗黑素细胞抗体。这些结果表明，补体结合性抗黑素细胞抗体与慢性黏膜皮肤念珠菌病相关，但不参与普通白癜风的发病机制。
