Mohs F E, Zitelli J A
Arch Dermatol. 1981 Dec;117(12):764-9.
Complete microscopic control of the excision of carcinomas of the scalp is of special benefit, because, in this location, there is an unusual tendency for outgrowths to extend for considerable distances beyond the clinically apparent borders of the neoplasms. Microscopic control is achieved through layer-by-layer excision of cancerous tissue and the use of frozen sections for systematic microscopic scanning of the undersurface of each layer. The reliability of this technique is demonstrated by the treatment results obtained in a series of 576 basal cell carcinomas. The cure rate for the 444 patients who were observed for five years or longer was 98.9%. In a series of 131 patients with squamous cell carcinomas, the cure rate for the 83 patients who were observed for five years or more was 98.8%. Conservation of maximal amounts of normal tissue is an added benefit of the microscopic control technique.
对头皮癌切除进行完整的显微镜下控制具有特殊益处，因为在此部位，肿瘤向外生长延伸至明显超出肿瘤临床边界的相当距离的趋势异于寻常。通过逐层切除癌组织并使用冰冻切片对每一层的底面进行系统显微镜扫描来实现显微镜下控制。在一系列576例基底细胞癌中所获得的治疗结果证明了该技术的可靠性。对观察五年或更长时间的444例患者而言，治愈率为98.9%。在一系列131例鳞状细胞癌患者中，对观察五年或更长时间的83例患者而言，治愈率为98.8%。最大限度保留正常组织是显微镜下控制技术的又一益处。
