Diószeghy P, Mechler F, Csenkér E
Arch Psychiatr Nervenkr (1970). 1981;230(4):307-14. doi: 10.1007/BF00346102.
The CPK, aldolase, GOT, GPT, and LDH concentrations in the serum and lumbar CSF of 80 patients with neuromuscular diseases and 20 controls were measured. The value obtained in serum was essentially in agreement with the data in the literature. This is the first publications reporting on regular CSF enzyme examinations in different neuromuscular disorders, particularly the results obtained in neurogenic muscular atrophies, which have certain characteristic features. The LDH activity in CSF was decreased in peroneal muscular atrophy, the GPT concentration in CSF was elevated in spinal muscular atrophy, and the mean activity of CSF aldolase was increased in amyotrophic lateral sclerosis. The simultaneous determination of enzymes in serum and CSF can provide valuable information in the research of certain details of pathomechanisms and thus lead to further improvement of diagnosis.
对80例神经肌肉疾病患者和20例对照者的血清及腰椎脑脊液中的肌酸磷酸激酶（CPK）、醛缩酶、谷草转氨酶（GOT）、谷丙转氨酶（GPT）和乳酸脱氢酶（LDH）浓度进行了测定。血清中获得的值与文献中的数据基本一致。这是首次报道对不同神经肌肉疾病进行常规脑脊液酶检查的出版物，特别是在具有某些特征的神经源性肌肉萎缩中获得的结果。在腓骨肌萎缩症中脑脊液中的LDH活性降低，在脊髓性肌萎缩症中脑脊液中的GPT浓度升高，在肌萎缩侧索硬化症中脑脊液醛缩酶的平均活性增加。同时测定血清和脑脊液中的酶可以为病理机制某些细节的研究提供有价值的信息，从而进一步改善诊断。
