[Effect of continuous movement restriction on pulmonary morphology in dogs].

By means of different histological and morphometric methods changes in vascular and tissue component structures have been studied in the lungs of 49 dogs constantly kept at restricted movement (in a specially constructed device) for 1, 3, 7, 15, 30, 60, and 90 days. Nearly in every period of the experiment edema is noted in the bronchial wall, in the perivasal and peribronchial connective tissue and in the interalveolar septa. In some parts of the lung the alveoles are emphisematously dilated, and some part of the interalveolar septa is thinned. With increasing time of hypokinesia the connective tissue gets coarse and the collagenous fibre fasciculi grow thicker along the course of the vascular bed, especially of the alveolar one. Thus, all the components are subjected to certain morphological alterations at hypokinesia, this, in its turn, affects the function of gas exchange.