Holmes J H, Humphrey J D, Walton E A, O'Shea J D
Aust Vet J. 1981 Jun;57(6):257-61. doi: 10.1111/j.1751-0813.1981.tb05805.x.
Gross and histopathological changes and serum thyroxine levels were determined in 10 heifers fed an exclusive diet of Leucaena leucocephala from 10 months of age until slaughter, 23 months later. Normal ovarian activity and mating were observed during a 7-month mating period. Cataracts, goitre, lingual epithelial ulceration and gingival atrophy were present at slaughter. Only one of the heifers was pregnant. Histologically, severe vacuolation and disruption of lens fibres and focal hyperplasia of lens epithelium were present. Both follicular hyperplasia and colloid accumulation were found to varying degrees in the thyroid glands and serum thyroxine levels were higher than in a comparable group of animals not fed L. leucocephala. Morphologically normal trophoblast was present in the uteri of 6 animals even though no embryo or foetus was present. Embryonic death and resorption may have been due to the anti-mitotic effect of mimosine or the goitrogenic effect of DHP.
对10头小母牛进行了研究，从10月龄开始直至23个月后屠宰，期间只喂食银合欢属植物，测定了它们的大体和组织病理学变化以及血清甲状腺素水平。在7个月的交配期内观察到正常的卵巢活动和交配情况。屠宰时发现有白内障、甲状腺肿、舌上皮溃疡和牙龈萎缩。只有1头小母牛怀孕。组织学检查发现，晶状体纤维严重空泡化和破坏，晶状体上皮灶性增生。甲状腺不同程度地出现滤泡增生和胶体蓄积，血清甲状腺素水平高于未喂食银合欢属植物的同龄动物组。6头动物的子宫内存在形态正常的滋养层，尽管没有胚胎或胎儿。胚胎死亡和吸收可能是由于含羞草碱的抗有丝分裂作用或3,4-二羟基苯丙氨酸的致甲状腺肿作用。
