Muers M F, Arnold A G, Sleight P
Br Heart J. 1981 Nov;46(5):539-44. doi: 10.1136/hrt.46.5.539.
A prospective trial was conducted to assess the value of prophylactic antibiotic treatment in preventing postoperative infection of permanent transvenous pacemaker systems. Four hundred and thirty-one patients were randomly allocated to treatment (234) or no-treatment (197) groups. Treated patients received systemic benzylpenicillin and flucloxacillin just before operation and one and six hours afterwards. Nine primary generator pocket infections occurred without evidence of wound dehiscence or skin erosion. Seven infections were in untreated patients and two in treated patients. Antibiotic prophylaxis diminishes the risk of infection after pacemaker implantations.
进行了一项前瞻性试验，以评估预防性抗生素治疗在预防永久性经静脉起搏器系统术后感染中的价值。431例患者被随机分为治疗组（234例）和非治疗组（197例）。治疗组患者在手术前、术后1小时和6小时接受全身性苄青霉素和氟氯西林治疗。发生了9例原发性发生器囊袋感染，无伤口裂开或皮肤糜烂迹象。7例感染发生在未治疗患者中，2例发生在治疗患者中。抗生素预防可降低起搏器植入后感染的风险。
