Grenadier A K, Panfilov A V
Biofizika. 1981 Nov-Dec;26(6):1107-8.
Sensitivity of two kinds of spiral wave sources of excitation of fast inward current (INa) inhibition was compared. These spiral wave sources were: circulation in a ring around an obstacle--re-entry and circulation in tissue without an obstacle--reverbarator (leading circle). It was shown that moderate inhibition of INa ceased the circulation of the reverbarator but was ineffective against the circulation in the ring. It is known that auricular flutter and fibrillation are based on wave circulation in the ring. So a conclusion was made that all antiarrhythmic drugs inhibiting mainly the sodium current should be ineffective against auricular flutter and fibrillation.
比较了两种快速内向电流（INa）抑制激发的螺旋波源的敏感性。这些螺旋波源为：围绕障碍物的环行——折返，以及在无障碍物组织中的环行——振子（主导环）。结果表明，适度抑制INa可使振子的环行停止，但对环中的环行无效。已知心房扑动和颤动基于环中的波环行。因此得出结论，所有主要抑制钠电流的抗心律失常药物对心房扑动和颤动均无效。
