Hill T L
Biophys Chem. 1981 Sep;14(1):31-44. doi: 10.1016/0301-4622(81)87004-4.
We Study models in which initial ligand molecules can bind on a linear array of sites only by lifting or moving an adjacent polymer molecule, over a range of a few binding sites, into a state of higher free energy. This inhibits the initial binding but subsequent ligand molecules can then bind more easily under the "umbrella" already lifted in the initial binding (a cooperative effect). Three subjects are considered: cooperative properties of a general model in which, besides the "umbrella" effect, the polymer is divided into m-site long segments, with interactions between the ends of these segments (section 3); application of this model to tropomyosin-troponin-myosin (section (a cooperative effect). Three subjects are considered: cooperative properties of a general model in which, besides the "umbrella" effect, the polymer is divided into m-site long segments, with interactions between the ends of these segments (section 3); application of this model to tropomyosin-troponin-myosin (section (a cooperative effect). Three subjects are considered: cooperative properties of a general model in which, besides the "umbrella" effect, the polymer is divided into m-site long segments, with interactions between the ends of these segments (section 3); application of this model to tropomyosin-troponin-myosin (section 2); and cooperative properties of simpler models in which the polymer is not divided into segments though the "umbrella" can have various ranges (section 4).
初始配体分子只能通过将相邻的聚合物分子提升或移动几个结合位点的范围，使其进入更高自由能状态，才能结合到线性位点阵列上。这抑制了初始结合，但随后的配体分子在初始结合时已经抬起的“保护伞”下（协同效应）可以更容易地结合。我们考虑三个主题：一个通用模型的协同性质，其中除了“保护伞”效应外，聚合物被分成m个位点长的片段，这些片段的末端之间存在相互作用（第3节）；该模型在原肌球蛋白 - 肌钙蛋白 - 肌球蛋白中的应用（第2节）（一种协同效应）。我们考虑三个主题：一个通用模型的协同性质，其中除了“保护伞”效应外，聚合物被分成m个位点长的片段，这些片段的末端之间存在相互作用（第3节）；该模型在原肌球蛋白 - 肌钙蛋白 - 肌球蛋白中的应用（第2节）；以及更简单模型的协同性质，其中聚合物不被分成片段，尽管“保护伞”可以有不同的范围（第4节）。
