Kryzhanovskiĭ G N, Lutsenko V K, Karganov M Iu, Torshin V I
Biull Eksp Biol Med. 1981 Oct;91(10):404-6.
A fraction consisting of low-molecular components (LMCs) was isolated from the brain of rats with unilateral destruction of the Deuters lateral vestibular nucleus (LVN) or with the generator of excitation (GE) created in the LVN with tetanus toxin. Intracranial administration of the preparation to normal rats produced the tension of body muscles, bending and opposite changes in the muscle tone of the hind limbs - the delay in the pulling up of the paw passively set aside and enhancement of the flexor tone of the opposite hind limb. The delayed pulling up of the hind paw in the recipients occurred on the side where the donors manifested an activated LVN (on the GE side or on the opposite side of the nucleus destruction). The effects cited did not occur if LMCs were exposed to proteolytic destruction or if the administration of LMCs was preceded by intraperitoneal injection of nalorphine, as well as if LMCs were administered in conjunction with naloxone. It is suggested that the test factors of the postural asymmetry are of peptide nature and that the opiate brain systems participate in the formation of the responses to their administration. A possible contribution of neurochemical lateralization of the brain to the phenomena of the "pathological condition transfer" is discussed.
从单侧损毁Deuters外侧前庭核（LVN）的大鼠大脑或用破伤风毒素在LVN中制造兴奋源（GE）的大鼠大脑中分离出一种由低分子成分（LMCs）组成的组分。将该制剂颅内注射给正常大鼠会引起身体肌肉紧张、后肢肌张力弯曲及相反变化——被动伸展的爪子向上拉起延迟以及对侧后肢屈肌肌张力增强。受体后爪向上拉起延迟出现在供体表现出LVN激活的一侧（在GE侧或核损毁的对侧）。如果LMCs受到蛋白水解破坏，或者在注射LMCs之前腹腔注射纳洛啡，以及将LMCs与纳洛酮联合注射时，上述效应均不会出现。提示姿势不对称的测试因子具有肽的性质，且阿片脑系统参与对其注射的反应形成。讨论了大脑神经化学侧化对“病理状态转移”现象的可能作用。
