Kryzhanovskiĭ G N, Lutsenko V K, Karganov M Iu
Biull Eksp Biol Med. 1982 Jan;93(1):14-6.
Suboccipital administration to rats of the solutions of substances extracted from the left and right halves of the brain with 1 M hot acetic acid gives rise to humping, restricts animals' mobility and induces asymmetric changes in the muscle tone of the hind limbs. The hind limb may be extended back or aside at the same side where brain extraction was performed and may retain this position for 25-30 sec. Proteolysis of the extracts or preliminary administration of nalorphine to the animals abolished the occurrence of, while suboccipital administration of naloxon removed the extract-evoked changes in the muscle tone. After application of the extracts to the spinal cord of the hordotomized (Th5-Th7) rats the electrical activity rose at the same side where brain extraction was performed, primarily in the m. quadriceps. It is assumed that active factors extracted from the left and right halves of the brain are different; they are endogenous opioid peptides or else their effects on the activity of spinal motoneurons are mediated via the opiate systems.
用1M热乙酸从大鼠左右半脑提取的物质溶液进行枕下给药，会引起弓背，限制动物活动，并导致后肢肌张力出现不对称变化。后肢可能会在进行脑提取物提取的同一侧向后或向一侧伸展，并可能保持该姿势25 - 30秒。提取物的蛋白水解或对动物预先给予纳洛芬可消除这种现象的发生，而枕下给予纳洛酮则可消除提取物引起的肌张力变化。将提取物应用于脊髓横断（Th5 - Th7）的大鼠脊髓后，在进行脑提取物提取的同一侧，电活动增强，主要在股四头肌。推测从左右半脑提取的活性因子不同；它们是内源性阿片肽，或者它们对脊髓运动神经元活动的影响是通过阿片系统介导的。
