Nezhentsev M V, Averburg K A, Livshin A M
Biull Eksp Biol Med. 1981 Nov;92(11):569-71.
Experiments on rats have shown that administration of hydrocortisone in a dose of 10 mg/kg, prednisolone in a dose of 2.5 mg/kg, dexamethasone (0.3 mg/kg) and triamcinolone (2 mg/kg) over 14 days result in the decreased number of fractions, in the redistribution of the drug content by fractions, and in the rise of the methemoglobin content. The carboxyhemoglobin content changes but little under the effect of hydrocortisone and prednisolone but significantly increases after dexamethasone and triamcinolone administration. In vitro experiments have shown that hormone preparations are capable of increasing the methemoglobin content at the expense of immediate effect on red cells.
对大鼠的实验表明，连续14天给予剂量为10毫克/千克的氢化可的松、2.5毫克/千克的泼尼松龙、0.3毫克/千克的地塞米松和2毫克/千克的曲安西龙，会导致组分数量减少、药物含量在各组分中的重新分布以及高铁血红蛋白含量升高。在氢化可的松和泼尼松龙的作用下，碳氧血红蛋白含量变化不大，但在地塞米松和曲安西龙给药后显著增加。体外实验表明，激素制剂能够通过直接作用于红细胞来增加高铁血红蛋白含量。
