Glashan R W, Wijesinghe D P, Riley A
Br J Urol. 1981 Dec;53(6):571-7. doi: 10.1111/j.1464-410x.1981.tb03263.x.
In the Huddersfield district many people have been exposed to industrial carcinogens as a result of their occupation. An exfoliative urine cytology screening programme has been in operation for many years so that patients with the early changes associated with these carcinogens are referred for urological investigation at a very early stage in the disease. A description of the development of urothelial dysplasia, carcinoma in situ and transitional cell carcinoma is presented with particular reference to the urine cytology, histological features of mucosal biopsies and cystoscopic appearances of the bladder. Changes in the collagen fibres in the basement membrane are also described.
在哈德斯菲尔德地区，许多人因职业原因接触到工业致癌物。一项尿液脱落细胞学筛查计划已经实施多年，以便那些出现与这些致癌物相关早期变化的患者在疾病的极早期就被转介进行泌尿外科检查。本文描述了尿路上皮发育异常、原位癌和移行细胞癌的发展情况，特别提及了尿液细胞学、黏膜活检的组织学特征以及膀胱的膀胱镜检查表现。还描述了基底膜中胶原纤维的变化。
