Hall R R, Heath A B
Br J Urol. 1981 Dec;53(6):598-601. doi: 10.1111/j.1464-410x.1981.tb03269.x.
The survival of 102 patients with category T3 transitional cell carcinoma of the bladder treated by pre-operative radiotherapy and radical cystectomy has been analysed according to the degree of down-staging of tumour as assessed by the depth of infiltration of cancer in the operative specimen. Five-year survival was 60% for patients showing evidence of down-staging compared with 30% when persistent deeply invasive tumour was present at the time of cystectomy. Analysis of available data suggests that survival of patients with category T3 bladder cancer is determined by the response of the tumour to initial radiotherapy rather than the dose of radiotherapy or the addition of cystectomy. Despite radical treatment, the survival of patients with locally advanced bladder cancer is poor; alternative, more effective forms of therapy should be sought.
根据手术标本中癌浸润深度评估的肿瘤降期程度，对102例接受术前放疗和根治性膀胱切除术的T3期膀胱移行细胞癌患者的生存情况进行了分析。有降期证据的患者5年生存率为60%，而膀胱切除术时存在持续深度浸润性肿瘤的患者5年生存率为30%。对现有数据的分析表明，T3期膀胱癌患者的生存取决于肿瘤对初始放疗的反应，而非放疗剂量或是否进行膀胱切除术。尽管进行了根治性治疗，局部晚期膀胱癌患者的生存率仍很低；应寻求其他更有效的治疗方法。
