McDermott F T, Hughes E S, Pihl E, Milne B J, Price A B
Br J Surg. 1981 Dec;68(12):846-9. doi: 10.1002/bjs.1800681206.
Between 1950 and 1978 754 patients underwent operation by one of the authors for carcinoma of the colon. Follow-up data were available on 99 per cent. Tumour stage distribution did not differ significantly with increasing duration of symptoms. The proportion of curative to palliative operative procedures was unrelated to symptom duration. Cancer specific survival for the entire patient series was worse when symptoms had been present for less than 3 months compared with 3-6 months, 6-12 months or 12 months or more (P less than 0.001, P less than 0.02 and P less than 0.04, respectively). Cancer specific survival after curative resection was also worse in patients with a symptom duration of less than 3 months compared with 3-6 months or 12 months or more (P less than 0.02 and P less than 0.03, respectively). These results show that colon cancer patients in whom the diagnosis is made and operation performed after a short symptomatic period do not have less advanced tumours nor better survival prospects.
1950年至1978年间，754例患者接受了本文作者之一实施的结肠癌手术。99%的患者有随访数据。肿瘤分期分布与症状持续时间增加无显著差异。根治性与姑息性手术比例与症状持续时间无关。与症状持续3 - 6个月、6 - 12个月或12个月及以上的患者相比，症状出现少于3个月的整个患者系列的癌症特异性生存率更差（分别为P < 0.001、P < 0.02和P < 0.04）。与症状持续3 - 6个月或12个月及以上的患者相比，症状持续时间少于3个月的患者根治性切除术后的癌症特异性生存率也更差（分别为P < 0.02和P < 0.03）。这些结果表明，在症状出现短时间后确诊并接受手术的结肠癌患者，肿瘤并非不那么晚期，生存前景也并非更好。
