Berry A R, Taylor T V, Davies G C
Br J Surg. 1981 Dec;68(12):870-3. doi: 10.1002/bjs.1800681212.
Respiratory complications were studied in 50 patients with acute pancreatitis, and the relationship of these complications to parameters of fibrinogen metabolism was investigated. The mean arterial P02 of the patients was 9.85 +/- 3.8 kPa (s.d.). Forty-three per cent of patients on admission were hypoxaemic. The mean PO2 was lower in patients who subsequently developed complications of acute pancreatitis (mean P02 7.85 +/- 1.42 kPa (s.d.), P less than 0.01). Vital capacity on admission was decreased by 50 per cent in 41 per cent of patients and by 20 per cent decrease in their vital capacity. Fibrinogen levels were elevated in 80 per cent of of patients on admission and there was a negative correlation between these levels and the arterial P02 (r = -0.6, P less than 0.001). Fibrinogen degradation products were elevated in 45 per cent of patients. The results confirm that marked lung damage occurs in acute pancreatitis and suggest that the effects are prolonged. The possibility that this damage may be related to pulmonary fibrin deposition is discussed.
对50例急性胰腺炎患者的呼吸并发症进行了研究，并探讨了这些并发症与纤维蛋白原代谢参数之间的关系。患者的平均动脉血氧分压为9.85±3.8 kPa（标准差）。43%的患者入院时存在低氧血症。随后发生急性胰腺炎并发症的患者平均血氧分压较低（平均血氧分压7.85±1.42 kPa（标准差），P<0.01）。41%的患者入院时肺活量下降了50%，另有部分患者肺活量下降了20%。80%的患者入院时纤维蛋白原水平升高，且这些水平与动脉血氧分压呈负相关（r = -0.6，P<0.001）。45%的患者纤维蛋白原降解产物升高。结果证实急性胰腺炎时发生了明显的肺损伤，且提示这种影响具有持续性。讨论了这种损伤可能与肺内纤维蛋白沉积有关的可能性。
