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大鼠肝脏提取物对肝毒素的反应促进DNA中O6-甲基鸟嘌呤的甲基基团向蛋白质转移。

Stimulation of transfer of methyl groups from O6-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins.

作者信息

Pegg A E, Perry W

出版信息

Carcinogenesis. 1981;2(11):1195-200. doi: 10.1093/carcin/2.11.1195.

DOI:10.1093/carcin/2.11.1195
PMID:7318156
Abstract

An enzymatic activity present in rat liver extracts catalyzes the transfer of methyl groups from O6-methylguanine in DNA to protein. This activity was stimulated by treatment of rats with thioacetamide, carbon tetrachloride, 1,2-dimethylhydrazine, diethylnitrosamine, dimethylnitrosamine and by partial hepatectomy but not by treatment with N-methyl-N-nitrosourea or streptozotocin. These results suggest that an enhancement of this activity accompanies the increase in cell division brought about by these agents and is not necessarily a specific response to the presence of alkylated bases in DNA.

摘要

大鼠肝脏提取物中存在的一种酶活性可催化DNA中O6-甲基鸟嘌呤的甲基基团转移至蛋白质上。用硫代乙酰胺、四氯化碳、1,2-二甲基肼、二乙基亚硝胺、二甲基亚硝胺处理大鼠以及进行部分肝切除可刺激这种活性，但用N-甲基-N-亚硝基脲或链脲佐菌素处理则不会。这些结果表明，这种活性的增强伴随着这些试剂引起的细胞分裂增加，并不一定是对DNA中烷基化碱基存在的特异性反应。

相似文献

1
Stimulation of transfer of methyl groups from O6-methylguanine in DNA to protein by rat liver extracts in response to hepatotoxins.大鼠肝脏提取物对肝毒素的反应促进DNA中O6-甲基鸟嘌呤的甲基基团向蛋白质转移。
Carcinogenesis. 1981;2(11):1195-200. doi: 10.1093/carcin/2.11.1195.
2
Enhanced repair of O6-methylguanine in liver DNA of rats pretreated with phenobarbital, 2,3,7,8-tetrachlorodibenzo-p-dioxin, ethionine, or N-alkyl-N-nitrosoureas.用苯巴比妥、2,3,7,8-四氯二苯并对二恶英、乙硫氨酸或N-烷基-N-亚硝基脲预处理的大鼠肝脏DNA中O6-甲基鸟嘌呤修复增强。
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3
Effect of partial hepatectomy on removal of O6-methylguanine from alkylated DNA by rat liver extracts.部分肝切除对大鼠肝脏提取物从烷基化DNA中去除O6-甲基鸟嘌呤的影响。
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Methylation of liver DNA guanine in hydrazine hepatotoxicity: dose-response and kinetic characteristics of 7-methylguanine and O6-methylguanine formation and persistence in rats.
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Metabolism of dimethylnitrosamine and subsequent removal of O6-methylguanine from DNA by isolated rat hepatocytes.二甲基亚硝胺的代谢以及分离的大鼠肝细胞随后从DNA中去除O6-甲基鸟嘌呤的过程。
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Comparison of the rates of repair of O6-alkylguanines in DNA by rat liver and bacterial O6-alkylguanine-DNA alkyltransferase.大鼠肝脏和细菌O6-烷基鸟嘌呤-DNA烷基转移酶对DNA中O6-烷基鸟嘌呤修复速率的比较。
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Effect of pretreatment of rats with N-methyl-N-nitrosourea on the repair of O(6)-methylguanine in liver DNA.用N-甲基-N-亚硝基脲预处理大鼠对肝脏DNA中O(6)-甲基鸟嘌呤修复的影响。
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Repair of O6-methyl-guanine residues in DNA takes place by a similar mechanism in extracts from HeLa cells, human liver, and rat liver.在来自HeLa细胞、人肝脏和大鼠肝脏的提取物中，DNA中O6-甲基鸟嘌呤残基的修复通过类似的机制进行。
J Cell Biochem. 1982;20(4):381-92. doi: 10.1002/jcb.240200408.

引用本文的文献

1
Adaptive increase of O6-methylguanine-acceptor protein in HeLa cells following N-methyl-N'-nitro-N-nitrosoguanidine treatment.经N-甲基-N'-硝基-N-亚硝基胍处理后，HeLa细胞中O6-甲基鸟嘌呤受体蛋白的适应性增加。
Nucleic Acids Res. 1982 Aug 11;10(15):4595-604. doi: 10.1093/nar/10.15.4595.
2
Cell-specific differences in O6-alkylguanine DNA repair activity during continuous exposure to carcinogen.持续暴露于致癌物期间O6-烷基鸟嘌呤DNA修复活性的细胞特异性差异。
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5499-502. doi: 10.1073/pnas.79.18.5499.
3
Removal of O6-methylguanine from DNA by human liver fractions.
人肝脏组分对DNA中O6-甲基鸟嘌呤的去除作用。
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5162-5. doi: 10.1073/pnas.79.17.5162.
4
Suicide inactivation of the E. coli O6-methylguanine-DNA methyltransferase.大肠杆菌O6-甲基鸟嘌呤-DNA甲基转移酶的自杀性失活
EMBO J. 1982;1(11):1359-63. doi: 10.1002/j.1460-2075.1982.tb01323.x.
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Adaptive response of Micrococcus luteus to alkylating chemicals.藤黄微球菌对烷基化化学物质的适应性反应。
Nucleic Acids Res. 1984 Feb 24;12(4):2111-26. doi: 10.1093/nar/12.4.2111.
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Proc Natl Acad Sci U S A. 1984 Feb;81(3):757-61. doi: 10.1073/pnas.81.3.757.
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