Norman R J, Green-Thompson R W, Jialal I, Soutter W P, Pillay N L, Joubert S M
Clin Endocrinol (Oxf). 1981 Oct;15(4):395-401. doi: 10.1111/j.1365-2265.1981.tb00680.x.
The thyroid status of twenty-seven African patients with gestational trophoblastic neoplasia (GTN) was studied. Fifteen patients were found to be biochemically hyperthyroid (eight patients with choriocarcinoma; seven with hydatidiform mole). Of these fifteen patients, nine were clinically thyrotoxic. The most serious complication of thyrotoxicosis was life-threatening acute pulmonary oedema with associated cardiac failure. It was found that when serum levels of the human chorionic gonadotrophin (hCG) reached a level of about 0.1 X 10(6) iu/1, thirteen of sixteen patients were biochemically hyperthyroid; at serum levels of 0.3 X 10(6) iu/1 of hCG most patients were clinically thyrotoxic. A feature of hyperthyroidism associated with GTN is that whereas T4 is invariably raised the T3:T4 ratio tends to be low (0.015 +/- 005); rT3:T3 ratios were high in this group. TSH levels were not increased.
对27例患有妊娠滋养细胞肿瘤（GTN）的非洲患者的甲状腺状态进行了研究。发现15例患者存在生化性甲状腺功能亢进（8例绒毛膜癌患者；7例葡萄胎患者）。在这15例患者中，9例临床上有甲状腺毒症。甲状腺毒症最严重的并发症是危及生命的急性肺水肿并伴有心力衰竭。研究发现，当人绒毛膜促性腺激素（hCG）血清水平达到约0.1×10⁶iu/1时，16例患者中有13例存在生化性甲状腺功能亢进；当hCG血清水平达到0.3×10⁶iu/1时，大多数患者临床上有甲状腺毒症。与GTN相关的甲状腺功能亢进的一个特点是，虽然T4总是升高，但T3:T4比值往往较低（0.015±0.005）；该组中反三碘甲状腺原氨酸（rT3）:T3比值较高。促甲状腺激素（TSH）水平未升高。
