Nuutinen J, Kärjä J
Clin Otolaryngol Allied Sci. 1981 Dec;6(6):415-9. doi: 10.1111/j.1365-2273.1981.tb01820.x.
There were 18 patients (16%) with metastatic squamous cell carcinoma of the lip in a total material of 114 operatively treated patients. There were initially palpable cervical nodes in 14% of the patients, but only 6 (5%) had histologically proved metastases. Two patients (1.8%) had distant metastases. The primary tumour in the metastatic group was classified as T1 in 3 (17%), T2 in 4 (22%) and T3 in 11 (61%) cases. During 5-year-follow-up of 73 of the patients, local recurrences were found in 10 cases (13.5%), 5 of whom developed subsequent metastases. Of the remaining 63 patients without local recurrences only 3 (5%) had metastases. Totally 8 of 73 patients, who had no metastases initially, developed them during 5-year-follow-up. Metastases appeared within three years after initial treatment. In the metastatic group only 15.5% of the patients are alive after 5 years, and totally 13.5% of the patients died of the carcinoma of the hip within in 5 years.
在114例接受手术治疗的患者中，有18例（16%）患有唇部转移性鳞状细胞癌。最初有14%的患者可触及颈部淋巴结，但只有6例（5%）经组织学证实有转移。2例（1.8%）有远处转移。转移性组中的原发肿瘤，3例（17%）为T1期，4例（22%）为T2期，11例（61%）为T3期。在对73例患者进行5年随访期间，发现10例（13.5%）有局部复发，其中5例随后发生转移。在其余63例无局部复发的患者中，只有3例（5%）发生转移。73例最初无转移的患者中，共有8例在5年随访期间发生转移。转移发生在初始治疗后的三年内。在转移性组中，只有15.5%的患者在5年后存活，共有13.5%的患者在5年内死于唇部癌。
