大鼠实验性原发性高血压？

Experimental essential hypertension in the rat?

Nowaczynski M, Nowaczynski W, Mavoungou D, Wilkins G, Fung K, Boyko R

Clin Sci (Lond). 1981 Dec;61 Suppl 7:355s-357s. doi: 10.1042/cs061355s.

Abstract

A human urinary thermostable glycoprotein (ABG-TsU) believed to be a homologue of the plasma aldosterone-binding globulin (ABG) was isolated and purified by differential ultrafiltration, ion-exchange chromatography and gel filtration to electrophoretic homogeneity; it showed a charge heterogeneity in electrofocussing. 2. ABG-TsU was administered intraperitoneally to male rats in small daily doses (7 microgram/day per rat). Sustained hypertension developed in 5--8 days. 3. The treated rats showed no changes in plasma electrolytes, aldosterone or plasma renin activity; however, a significant increase in heart weight was observed. 4. This hypertension appears to be adrenal dependent since it is prevented by bilateral adrenalectomy or administration of an aldosterone antagonist, but not by adrenalectomy when aldosterone is given concomitantly with ABG-TsU.

摘要

通过差速超滤、离子交换色谱和凝胶过滤法分离并纯化了一种被认为是血浆醛固酮结合球蛋白（ABG）同源物的人尿热稳定糖蛋白（ABG-TsU），直至达到电泳均一性；它在等电聚焦中显示出电荷不均一性。2. 以小剂量每日（每只大鼠7微克/天）腹腔内给予雄性大鼠ABG-TsU。5至8天内出现持续性高血压。3. 经治疗的大鼠血浆电解质、醛固酮或血浆肾素活性无变化；然而，观察到心脏重量显著增加。4. 这种高血压似乎依赖肾上腺，因为双侧肾上腺切除术或给予醛固酮拮抗剂可预防，但在ABG-TsU与醛固酮同时给予时，肾上腺切除术则无法预防。