自发性高血压大鼠和正常血压大鼠的细胞内阳离子活性与浓度

Intracellular cation activities and concentrations in spontaneously hypertensive and normotensive rats.

Zidek W, Vetter H, Zumkley H, Losse H

Clin Sci (Lond). 1981 Dec;61 Suppl 7:41s-43s. doi: 10.1042/cs061041s.

Abstract

The intracellular concentrations of Na+,K+ and Ca2+ were measured in the erythrocytes of spontaneously hypertensive rats and normotensive Wistar rats. 2. The intracellular Na+ concentration in hypertensive rats was slightly elevated at 3.16 +/- 0.25 compared with 2.85 +/- 0.35 mmol/l (P approximately 0.05) and intracellular Na+ activity was markedly increased in hypertensive rats. 3. Intracellular Ca2+ activity was 7519 +/- 28990 nmol/l of free water in hypertensive rats compared with 123 +/- 98 in controls (P less than 0.01). 4. The cytoplasm of hypertensive animals did not buffer Ca2+ as effectively as that of normal animals. 5. It is concluded that a decreased binding capacity of intracellular macromolecules for Na+ and Ca2+ may explain the disturbances of intracellular electrolyte composition in spontaneously hypertensive rats.

摘要

测定了自发性高血压大鼠和正常血压Wistar大鼠红细胞内的Na⁺、K⁺和Ca²⁺浓度。2. 高血压大鼠细胞内Na⁺浓度略有升高，为3.16±0.25 mmol/L，而正常血压大鼠为2.85±0.35 mmol/L（P约为0.05），且高血压大鼠细胞内Na⁺活性显著增加。3. 高血压大鼠细胞内Ca²⁺活性为7519±28990 nmol/L游离水，而对照组为123±98（P<0.01）。4. 高血压动物的细胞质对Ca²⁺的缓冲能力不如正常动物。5. 得出结论，细胞内大分子对Na⁺和Ca²⁺的结合能力降低可能解释自发性高血压大鼠细胞内电解质组成的紊乱。