Kopp S J, Greiner J V, Glonek T
Curr Eye Res. 1981;1(7):375-80. doi: 10.3109/02713688109019974.
Using phosphorus-31 nuclear magnetic resonance (P-31 NMR) spectroscopy the rat crystalline lens was evaluated as a potential animal model for the study of lens metabolic processes relevant to the human. The P-31 NMR spectra of intact rat lenses and rat lens PCA extracts provided comparable qualitative and quantitative results concerning the tissue levels of the phosphorus-containing metabolites of intermediate metabolism. The study also establishes the feasibility of examining intact rat lens metabolism by P-31 NMR. Comparisons with reported human and rabbit lens metabolite levels revealed significant differences; consequently, metabolic information derived from rat lens studies should be extrapolated to the human with caution.
利用磷-31核磁共振（P-31 NMR）光谱法，对大鼠晶状体进行评估，以确定其作为研究与人类相关的晶状体代谢过程的潜在动物模型。完整大鼠晶状体和大鼠晶状体PCA提取物的P-31 NMR光谱，在中间代谢含磷代谢物的组织水平方面提供了可比的定性和定量结果。该研究还确定了通过P-31 NMR检查完整大鼠晶状体代谢的可行性。与已报道的人类和兔晶状体代谢物水平的比较显示出显著差异；因此，从大鼠晶状体研究中获得的代谢信息外推至人类时应谨慎。
