奎尼丁蛋白结合的年龄相关差异。

Age-related differences in the protein binding of quinidine.

作者信息

Pickoff A S, Kessler K M, Singh S, Wolff G S, Tamer D F, Garcia O L, Gelband H

出版信息

Dev Pharmacol Ther. 1981;3(2):108-15. doi: 10.1159/000457429.

Abstract

The in vitro serum protein binding of quinidine was determined in 26 pediatric patients. Group I consisted of 6 cord blood samples obtained at the time of delivery, group II of 8 infants aged 8-18 months, and group III of 12 children over the age of 2 years. The percentage of free quinidine in group I was 39.2 +/- 10.8, group II 24.4 +/- 10.6 and group III 16.6 +/- 6.5, demonstrating a larger proportion of unbound quinidine in the newborn group and an increase in protein binding with age (p less than 0.0001). Therefore, the protein binding of quinidine is diminished in the neonate and young infant and may result in enhanced quinidine activity.

摘要

在26名儿科患者中测定了奎尼丁的体外血清蛋白结合率。第一组包括6份分娩时采集的脐血样本，第二组为8名8至18个月大的婴儿，第三组为12名2岁以上的儿童。第一组中游离奎尼丁的百分比为39.2±10.8，第二组为24.4±10.6，第三组为16.6±6.5，表明新生儿组中未结合奎尼丁的比例更大，且蛋白结合率随年龄增长而增加（p<0.0001）。因此，新生儿和幼儿中奎尼丁的蛋白结合率降低，可能导致奎尼丁活性增强。