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本文引用的文献

1
Ontogeny of hepatic and renal systemic clearance pathways in infants: part II.婴儿肝脏和肾脏全身清除途径的个体发生：第二部分。
Clin Pharmacokinet. 2002;41(13):1077-94. doi: 10.2165/00003088-200241130-00005.
2
Ontogeny of hepatic and renal systemic clearance pathways in infants: part I.婴儿肝脏和肾脏全身清除途径的个体发生：第一部分。
Clin Pharmacokinet. 2002;41(12):959-98. doi: 10.2165/00003088-200241120-00003.
3
Alpha-1-acid glycoprotein.α-1-酸性糖蛋白
Biochim Biophys Acta. 2000 Oct 18;1482(1-2):157-71. doi: 10.1016/s0167-4838(00)00153-9.
4
Fatty acid binding to human serum albumin: new insights from crystallographic studies.脂肪酸与人血清白蛋白的结合：晶体学研究的新见解。
Biochim Biophys Acta. 1999 Nov 23;1441(2-3):131-40. doi: 10.1016/s1388-1981(99)00148-1.
5
Evidence for differences in the binding of drugs to the two main genetic variants of human alpha 1-acid glycoprotein.药物与人类α1-酸性糖蛋白两种主要基因变体结合存在差异的证据。
Br J Clin Pharmacol. 1993 Sep;36(3):241-9. doi: 10.1111/j.1365-2125.1993.tb04224.x.
6
Fentanyl and alfentanil plasma protein binding in preterm and term neonates.芬太尼和阿芬太尼在早产和足月新生儿中的血浆蛋白结合情况。
Anesth Analg. 1997 Feb;84(2):315-8. doi: 10.1097/00000539-199702000-00013.
7
Binding of disopyramide, methadone, dipyridamole, chlorpromazine, lignocaine and progesterone to the two main genetic variants of human alpha 1-acid glycoprotein: evidence for drug-binding differences between the variants and for the presence of two separate drug-binding sites on alpha 1-acid glycoprotein.双异丙吡胺、美沙酮、双嘧达莫、氯丙嗪、利多卡因和孕酮与人α1-酸性糖蛋白两种主要基因变体的结合：变体间药物结合差异及α1-酸性糖蛋白上存在两个独立药物结合位点的证据
Pharmacogenetics. 1996 Oct;6(5):403-15. doi: 10.1097/00008571-199610000-00004.
8
Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part I: Phenobarbital, primidone, valproic acid, ethosuximide and mesuximide.抗癫痫药物在儿科患者中的临床药代动力学。第一部分：苯巴比妥、扑米酮、丙戊酸、乙琥胺和甲琥胺。
Clin Pharmacokinet. 1995 Oct;29(4):257-86. doi: 10.2165/00003088-199529040-00005.
9
Fractionation of the genetic variants of human alpha 1-acid glycoprotein in the native form by chromatography on an immobilized copper(II) affinity adsorbent. Heterogeneity of the separate variants by isoelectrofocusing and by concanavalin A affinity chromatography.通过固定化铜（II）亲和吸附剂上的色谱法对天然形式的人α1-酸性糖蛋白的遗传变体进行分级分离。通过等电聚焦和伴刀豆球蛋白A亲和色谱法对分离出的变体进行异质性分析。
J Chromatogr. 1993 May 19;615(1):47-57.
10
In vitro protein binding of cefonicid and cefuroxime in adult and neonatal sera.头孢尼西和头孢呋辛在成人及新生儿血清中的体外蛋白结合情况。
Antimicrob Agents Chemother. 1993 Jun;37(6):1343-7. doi: 10.1128/AAC.37.6.1343.

婴儿体内蛋白质结合预测

Protein binding predictions in infants.

作者信息

McNamara Patrick J, Alcorn Jane

机构信息

Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, USA.

出版信息

AAPS PharmSci. 2002;4(1):E4. doi: 10.1208/ps040104.

DOI:10.1208/ps040104
PMID:12049488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2751289/
Abstract

Plasma binding protein levels are lower in the newborn than in the adult and gradually increase with age. At birth, human serum albumin (HSA) concentrations are close to adult levels (75%-80%), while alpha 1-acid glycoprotein (AAG) is initially half the adult concentration. As a result, the extent of drug binding to HSA is closer to that of the adult than are those drugs bound largely to AAG. A model that incorporates the fraction unbound in adults and the ratio of the binding protein concentration between infants and adults successfully predicted the fraction unbound in infants and children.

摘要

新生儿的血浆结合蛋白水平低于成年人，并随年龄逐渐升高。出生时，人血清白蛋白（HSA）浓度接近成人水平（75%-80%），而α1-酸性糖蛋白（AAG）最初是成人浓度的一半。因此，与HSA结合的药物程度比那些主要与AAG结合的药物更接近成人。一个纳入成人游离分数以及婴儿与成人结合蛋白浓度之比的模型成功预测了婴儿和儿童的游离分数。