去酪氨酸1-γ-内啡肽增强吗啡对大鼠的镇痛效果。
Des-tyrosine1-gamma-endorphin increases the antinociceptive efficacy of morphine in the rat.
作者信息
Neil A, Lahti R A, Lindeberg G, Terenius L
出版信息
Eur J Pharmacol. 1981 Nov 19;76(1):93-5. doi: 10.1016/0014-2999(81)90014-5.
PMID:7318926
Abstract
Repeated injections of des-tyrosine1-gamma-endorphin (DT gamma E) to rats subjectively increased sensitivity to handling. After 8 days of treatment, the animals were supersensitive to a low dose of morphine in the foot-shock test. Acute treatment with DT gamma E gave no significant increase in morphine sensitivity. The results indicate that DTgammaE given chronically interacts with opioid receptor-effector mechanisms.
摘要
对大鼠反复注射去酪氨酸1-γ-内啡肽（DTγE）会主观上增加其对触摸的敏感性。治疗8天后，在足部电击试验中，这些动物对低剂量吗啡超敏感。DTγE的急性治疗并未使吗啡敏感性显著增加。结果表明，长期给予DTγE会与阿片受体效应机制相互作用。
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