[Clinico-biochemical study on Ishibashi rats (author's transl)].

Ishibashi rats, a mutant strain with congenital spinal malformation discovered by Ishibashi in 1968, are generally regarded as an animal model for a human inborn error of spinal malformation. Biochemical values in serum or plasma of Ishibashi rats were compared with those of Wistar-Imamichi rats, and the following results were obtained: 1) In Ishibashi rat sera, alkaline phosphatase activity was significantly lower than that in sera of controls, and an intestinal type of isozyme was hardly detected. 2) All other serum biochemical parameters examined showed no significant difference between Ishibashi and Wistar-Imamichi rats. 3) The data suggest that Ishibashi rats may serve as an animal model of hypophosphatasia in man.