Shinoda M, Kurosawa T, Maejima K, Watarai S
Jikken Dobutsu. 1981 Oct;30(4):481-5. doi: 10.1538/expanim1978.30.4_481.
The heart weight of germfree mice has been reported to be lighter than that of conventional mice. The difference in heart function between these mice, however, has not been well investigated. In the present study, we recorded ECGs of germfree, ex-germfree and conventional mice anesthetized with pentobarbitone sodium and weighed the hearts of these animals. On ECGs, there was no significant difference between germfree and conventional mice except QT and PP intervals, which were shorter in male germfree mice than those in male conventional mice. It was found that the heart weight of germfree mice was significantly lighter than that of conventional mice in both sexes. It was concluded that although the heart weight between germfree and conventional mice was different, the heart function evaluated using the ECG was not.
据报道，无菌小鼠的心脏重量比普通小鼠轻。然而，这些小鼠之间心脏功能的差异尚未得到充分研究。在本研究中，我们记录了用戊巴比妥钠麻醉的无菌、脱无菌和普通小鼠的心电图，并对这些动物的心脏进行称重。在心电图上，无菌小鼠和普通小鼠之间除QT和PP间期外无显著差异，雄性无菌小鼠的QT和PP间期比雄性普通小鼠短。结果发现，无菌小鼠的心脏重量在两性中均显著轻于普通小鼠。得出的结论是，尽管无菌小鼠和普通小鼠的心脏重量不同，但使用心电图评估的心脏功能并无差异。
