Pick J B, Evans C A
Experientia. 1981 Nov 15;37(11):1189-91. doi: 10.1007/BF01989912.
DNA synthesis in palatal processes obtained from fetal rats was 36% lower in the presence of excess vitamin A, but vitamin A-exposed maxillary explants showed only a modest decrease. Scanning electron micrographs of fetuses exposed to hypervitaminosis A in utero demonstrated both decreased head size and stunted palatal processes. The results suggest that cleft palates occur in this model system because the palatal processes are more sensitive to the actions of vitamin A than are the surrounding maxillary tissues.
在过量维生素A存在的情况下，从胎鼠获得的腭突中的DNA合成降低了36%，但暴露于维生素A的上颌外植体仅显示出适度的降低。子宫内暴露于维生素A过多症的胎儿的扫描电子显微镜照片显示头部尺寸减小和腭突发育不良。结果表明，在这个模型系统中发生腭裂是因为腭突比周围的上颌组织对维生素A的作用更敏感。
