Miura T
Hand. 1981 Oct;13(3):267-70. doi: 10.1016/s0072-968x(81)80007-1.
Congenital abnormalities of other parts occurring in patients with congenital abnormalities of the hand were studied. Hands and feet often showed similar anomalies, but there were cases in which the hands and feet had different kinds of deformity. Anomalies of the internal organs were associated with anomalies of the thumb. Cleft lip and palate occurred in combination with syndactyly, split hand, preaxial polydactyly and construction ring syndrome. Combined anomalies may be the result of a genetic or environmental factor interfering with parts developing during the same critical period. The critical period and probable pathogenesis are discussed and the conclusion reached that mesenchymal necrosis, abnormal distribution of mesenchyme and tissue necrosis after mesenchymal condensation may be the pathological changes which lead to abnormal development of the hand.
对患有手部先天性畸形的患者出现的其他部位先天性畸形进行了研究。手和脚常表现出相似的异常，但也有手和脚出现不同类型畸形的病例。内脏异常与拇指异常相关。唇腭裂与并指、裂手、轴前多指及束带综合征合并发生。合并畸形可能是由于遗传或环境因素在同一关键时期干扰了各部位的发育。讨论了关键时期和可能的发病机制，得出结论：间充质坏死、间充质分布异常以及间充质凝聚后的组织坏死可能是导致手部发育异常的病理变化。
