Zimmerman K G, Sobonya R E, Payne C M
Hum Pathol. 1981 Nov;12(11):1046-51. doi: 10.1016/s0046-8177(81)80267-5.
An autopsy case is presented in which a pulmonary carcinosarcoma filled the left chest of a 61 year old man. The extensive pleural involvement that this neoplasm exhibited has not been reported previously. By light microscopy the neoplasm initially was considered a mesothelioma because of the pattern of glands and undifferentiated sarcomatous stroma. However, by electron microscopy the sarcomatous component was found to show rhabdomyoblastic differentiation. Neither histochemical stains nor electron microscopy supported a mesothelial origin for the glandular component. Differential diagnostic considerations of pleuropulmonary neoplasms showing rhabdomyosarcomatous differentiation are discussed. This case illustrates the importance of detailed study in order to characterize and properly classify these neoplasms.
本文报告一例尸检病例,一名61岁男性的左胸被肺肉瘤样癌填满。该肿瘤广泛累及胸膜,此前未见相关报道。光镜下,由于肿瘤呈现腺体及未分化肉瘤样间质的形态,最初被认为是间皮瘤。然而,电镜检查发现肉瘤成分显示横纹肌母细胞分化。组织化学染色及电镜检查均不支持腺体成分来源于间皮。文中讨论了表现为横纹肌肉瘤样分化的胸膜肺肿瘤的鉴别诊断要点。该病例说明了详细研究对于这些肿瘤进行特征描述及正确分类的重要性。