Mukonoweshuro Pinias, Attanoos Richard L, Smith Mark E F
Department of Histopathology, Derriford Hospital, Plymouth, UK.
Virchows Arch. 2006 Aug;449(2):253-7. doi: 10.1007/s00428-006-0226-1.
An unusual diffuse pleural-based tumor arising in an elderly asbestos-exposed male is presented. The tumor presented in a 72-year-old male with a 30-year history of dockyard work and likely significant asbestos exposure. Macroscopically, at post mortem, the pleural tumor diffusely encased the right lung and was composed of an admixture of neoplastic macro-, and by light microscopy, micro-nodules. Histologically, the tumor had a biphasic growth pattern with glomeruloid epithelioid elements and immature blastematous mesenchymal stroma. Immunophenotypically, the tumor had a complex pattern with epithelioid elements expressing cytokeratins, desmin, carcinoembryonic antigen (CEA), Ber EP4 and E-cadherin. The diagnostic problems and medicolegal issues surrounding the diagnosis and differentiation from malignant pleural mesothelioma and other tumors are discussed.
本文报告了一例发生在一名有石棉接触史的老年男性身上的罕见弥漫性胸膜肿瘤。该肿瘤发生在一名72岁男性身上，他有30年的造船厂工作史，可能有大量石棉接触史。大体上，尸检时胸膜肿瘤弥漫性包裹右肺，由肿瘤性大结节和显微镜下的小结节混合组成。组织学上，肿瘤具有双相生长模式，有肾小球样上皮样成分和未成熟的母细胞性间充质基质。免疫表型上，肿瘤具有复杂的模式，上皮样成分表达细胞角蛋白、结蛋白、癌胚抗原（CEA）、Ber EP4和E-钙黏蛋白。讨论了围绕该肿瘤诊断以及与恶性胸膜间皮瘤和其他肿瘤鉴别的诊断问题和法医学问题。
