Ginsberg-Fellner F
Int J Obes. 1981;5(6):605-11.
In order to identify factors important in the growth of adipose tissue, four groups of children were studied. Infants of gestational diabetic mothers demonstrated increased fat cell numbers as early as age two months, a finding which accelerated with increasing age, and which was associated with persistent hyperinsulinemia and increasing obesity. Children with growth hormone deficiency increased their adipose cell number following treatment with exogenous hormone. Patients with the Prader-Willi syndrome, who developed obesity after the age of two, did so primarily via increases in fat cell size. Identical twins who were concordant for birthweight continued to have similar weights and total adipocyte numbers, while in those with discordant birthweights the smaller twin displays lower body weight and adipose cell number. The data indicate that growth hormone and insulin, as well as genetic factors, which may be modified by the in-utero environment, are important determinants of human adipose tissue mass.
为了确定对脂肪组织生长至关重要的因素，对四组儿童进行了研究。患有妊娠糖尿病母亲的婴儿早在两个月大时就表现出脂肪细胞数量增加，这一发现随着年龄增长而加速，并且与持续性高胰岛素血症和肥胖增加有关。生长激素缺乏的儿童在接受外源性激素治疗后脂肪细胞数量增加。普拉德-威利综合征患者在两岁后出现肥胖，主要是通过脂肪细胞大小增加实现的。出生体重一致的同卵双胞胎体重和脂肪细胞总数持续相似，而出生体重不一致的双胞胎中，较小的双胞胎体重和脂肪细胞数量较低。数据表明，生长激素、胰岛素以及可能受子宫内环境影响的遗传因素是人类脂肪组织量的重要决定因素。
