Epstein M, DeNunzio A G, Loutzenhiser R D
J Appl Physiol Respir Environ Exerc Physiol. 1981 Dec;51(6):1384-7. doi: 10.1152/jappl.1981.51.6.1384.
Although previous studies have demonstrated that water immersion to the neck (NI) results in a significant diuresis, the mechanisms are incompletely delineated. Because recent studies in our laboratory have demonstrated that NI is associated with a suppression of antidiuretic hormone (ADH), it is possible that such a suppression mediates the encountered diuresis. The present study was undertaken to assess more directly the relative role of ADH suppression by determining the effects of vasopressin administration. Six hydrated normal subjects were studied on two occasions while undergoing 6 h of NI. During the second NI study, aqueous vasopressin (20 mU/h) was infused for the initial 4 h of study (NI + vasopressin). NI resulted in a significant increase in urinary flow rate beginning during hour 1 and persisting throughout NI. In contrast, during NI + vasopressin, the anticipated diuresis was abolished throughout the 4 h of vasopressin administration. Cessation of vasopressin administration during the final 2 h of NI + vasopressin resulted in a marked and prompt diuresis. The present observations are consistent with the formulation that ADH suppression participates importantly in mediating the diuresis of NI in hydrated normal subjects.
尽管先前的研究表明，颈部水浸（NI）会导致显著的利尿，但其中的机制尚未完全阐明。由于我们实验室最近的研究表明，NI与抗利尿激素（ADH）的抑制有关，因此这种抑制可能介导了所观察到的利尿现象。本研究旨在通过确定血管加压素给药的效果，更直接地评估ADH抑制的相对作用。六名水合状态正常的受试者在两次实验中接受了6小时的NI。在第二次NI实验期间，在研究的最初4小时内输注了水剂血管加压素（20 mU/h）（NI + 血管加压素）。NI导致尿流率从第1小时开始显著增加，并在整个NI期间持续。相比之下，在NI + 血管加压素期间，在血管加压素给药的4小时内预期的利尿被消除。在NI + 血管加压素的最后2小时停止血管加压素给药导致显著且迅速的利尿。目前的观察结果与以下观点一致，即ADH抑制在介导水合状态正常的受试者NI利尿中起重要作用。
