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在诱发急性噪声性创伤之前和之后,由短纯音诱发的猫的第八神经动作电位。

Eighth-nerve action potentials evoked by tone bursts in cats before and after inducement of an acute noise trauma.

作者信息

Van Heusden E, Smoorenburg G F

出版信息

Hear Res. 1981 Sep;5(1):1-23. doi: 10.1016/0378-5955(81)90024-1.

DOI:10.1016/0378-5955(81)90024-1
PMID:7319931
Abstract

Properties of eighth-nerve action potentials (AP) evoked by single-frequency tone-bursts (test tone) were studied in cats. Curves representing AP threshold as a function of test-tone frequency have a shape similar to behavioral and single-fiber threshold curves. The absolute level of AP thresholds is higher than that of behavioral and single-fiber thresholds. Cats were exposed to broad-band noise (equal intensities per octave) halfway into the experiments. This exposure resulted in a long-term temporary threshold shift (TTS) which remained fairly steady during the measurements. APs were measured before and during an acute noise trauma in the same animal. After inducement of the trauma the greatest threshold shift is found between 2 and 6 kHz. Curves representing AP amplitude as a function of stimulus SPL are displaced to higher stimulus SPLs. Sometimes the slope of the curve is steeper after the noise exposure than before. AP latency at threshold did not change due to the excessive noise exposure. AP-latency values compared at equal sound pressure levels before and after inducement of the trauma showed higher values during the trauma than before.

摘要

在猫身上研究了由单频短纯音(测试音)诱发的第八对脑神经动作电位(AP)的特性。表示AP阈值作为测试音频率函数的曲线,其形状与行为阈值曲线和单纤维阈值曲线相似。AP阈值的绝对水平高于行为阈值和单纤维阈值。在实验进行到一半时,让猫暴露于宽带噪声(每倍频程强度相等)。这种暴露导致了长期的暂时性阈移(TTS),在测量过程中该阈移保持相当稳定。在同一动物的急性噪声损伤之前和期间测量AP。诱发损伤后,在2至6千赫兹之间发现最大的阈值变化。表示AP幅度作为刺激声压级(SPL)函数的曲线向更高的刺激SPL位移。有时,噪声暴露后曲线的斜率比之前更陡。阈值处的AP潜伏期没有因过度噪声暴露而改变。在诱发损伤前后,在相等声压级下比较的AP潜伏期值显示,损伤期间的值高于损伤前。

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