Zuraw B L, O'Hair C H, Vaughan J H, Mathison D A, Curd J G, Katz D H
J Clin Invest. 1981 Dec;68(6):1610-3. doi: 10.1172/jci110418.
A solid-phase radioimmunoassay was developed to detect immunoglobulin (Ig)E antibodies that bound to human IgG. IgE-rheumatoid factor activity was found in the serum of 18 of 20 patients with seropositive rheumatoid arthritis, 1 of 4 patients with seronegative rheumatoid arthritis, 3 of 32 patients with seronegative rheumatoid arthritis, 3 of 32 patients with asthma, and in 1 patient with hypocomplementemic vasculitis and iodide sensitivity. Immunopathologic implications of IgE-rheumatoid factor are discussed.
开发了一种固相放射免疫测定法来检测与人IgG结合的免疫球蛋白(Ig)E抗体。在20例血清阳性类风湿性关节炎患者中的18例、4例血清阴性类风湿性关节炎患者中的1例、32例血清阴性类风湿性关节炎患者中的3例、32例哮喘患者中的3例以及1例伴有低补体血症性血管炎和碘过敏的患者血清中发现了IgE类风湿因子活性。讨论了IgE类风湿因子的免疫病理学意义。