类风湿关节炎及其他关节炎中的IgG抗球蛋白：与临床特征及其他参数的关系
IgG antiglobulins in rheumatoid arthritis and other arthritides: relationship with clinical features and other parameters.
作者信息
Allen C, Elson C J, Scott D G, Bacon P A, Bucknall R C
出版信息
Ann Rheum Dis. 1981 Apr;40(2):127-31. doi: 10.1136/ard.40.2.127.
Abstract
A radioimmunoassay has been developed for measuring IgG antiglobulins using baboon IgG as antigen. Raised levels were virtually confined to the sera of patients with rheumatoid arthritis (RA) and not found in other seronegative arthritides. High levels were found in both seropositive and seronegative (as judged by latex slide and sheep cell differential agglutination for IgM antiglobulins) patients with RA and were associated with systemic disease but not synovitis. Very high levels (more than twice the upper limit of normal) showed a strong association with vasculitis.
摘要
已开发出一种放射免疫测定法，以狒狒免疫球蛋白G（IgG）作为抗原，用于检测IgG抗球蛋白。升高的水平实际上仅限于类风湿性关节炎（RA）患者的血清，在其他血清阴性关节炎中未发现。在RA的血清阳性和血清阴性（根据IgM抗球蛋白的乳胶玻片和绵羊细胞鉴别凝集判断）患者中均发现高水平，且与全身性疾病相关，但与滑膜炎无关。非常高的水平（超过正常上限的两倍）与血管炎有很强的相关性。
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