Greenwood R S, Godar S E, Reaves T A, Hayward J N
J Comp Neurol. 1981 Dec 10;203(3):335-50. doi: 10.1002/cne.902030303.
The distribution of cholecystokininlike (CCK-L) immunoreactive cells and fibers in the rat hippocampal formation and its afferent and efferent connections was studied using the immunoperoxidase technique. In the hippocampal formation CCK-L immunoreactive perikarya were located in the polymorphic zone of the dentate hilus, all layers of Ammon's horn, the subiculum, the presubiculum, and the entorhinal cortex. Cholecystokininlike immunoreactive fibers extended from cell bodies or were located around the cell bodies in the entorhinal cortex, subiculum and stratum pyramidale of Ammon's horn, and among the granule cells and inner molecular layer of the dentate gyrus. The immunoreactive cells in the stratum oriens may be a type of basket cell, since processes from these cells extend into stratum pyramidale and collections of CCK-L immunoreactive fibers are seen around cell bodies in stratum pyramidale. Cholecystokininlike immunoreactive fibers were also observed in the alveus, ventral and lateral fimbria, and ventrolateral lateral septal nucleus. Some of these immunoreactive fibers, therefore, being to either an efferent or afferent hippocampal pathway(s) originating from CCK-L immunoreactive pyramidal cells in the hippocampal formation and/or from the hippocampal subcortical nuclei, the supramammillary nucleus, and the dorsomedial hypothalamic nucleus which contain CCK-L immunoreactive perikarya. The distribution of these immunoreactive fibers in the fimbria and lateral septal nucleus is most consistent with an anteriorly directed efferent hippocampal pathway.
采用免疫过氧化物酶技术研究了胆囊收缩素样（CCK-L）免疫反应性细胞和纤维在大鼠海马结构及其传入和传出连接中的分布。在海马结构中，CCK-L免疫反应性核周体位于齿状回门的多形层、海马角各层、下托、前下托和内嗅皮质。胆囊收缩素样免疫反应性纤维从细胞体延伸出来，或位于内嗅皮质、下托和海马角锥体层的细胞体周围，以及齿状回颗粒细胞和内分子层之间。海马原层中的免疫反应性细胞可能是一种篮状细胞，因为这些细胞的突起延伸到锥体层，并且在锥体层的细胞体周围可见CCK-L免疫反应性纤维束。在海马槽、腹侧和外侧穹窿以及腹外侧隔核中也观察到胆囊收缩素样免疫反应性纤维。因此，这些免疫反应性纤维中的一些属于源自海马结构中CCK-L免疫反应性锥体细胞和/或源自含有CCK-L免疫反应性核周体的海马皮质下核、乳头体上核和下丘脑背内侧核的传出或传入海马通路。这些免疫反应性纤维在穹窿和隔核中的分布与向前的传出海马通路最为一致。
