Imataka K, Yamaoki K, Oouchi Y, Yazaki Y
J Cardiogr. 1981 Jun;11(2):449-56.
Six juvenile hypertensive patients were studied by supine bicycle ergometer exercise during continuous echocardiographic recording. Thirteen normotensive young men were also studied for the control. Left ventricular end-diastolic dimensions (Dd) during exercise was significantly increased from 28.8 +/- 0.5 mm/m2 to 29.7 +/- 0.6 mm/m2 in normotensives, but the increase in Dd was not observed in hypertensives. Effects of propranolol on changes in Dd during exercise were almost equal in two groups. Left ventricular end-systolic dimensions (Ds) were decreased during exercise in both groups. After propranolol administration, Ds in hypertensives was significantly increased from 18.8 +/- 1.0 mm/m2 to 19.4 +/- 1.1 mm/m2 at rest, and during the following exercise it reached to 19.7 +/- 1.1 mm/m2, whereas Ds in normotensives was decreased during exercise even after propranolol. Peripheral vascular resistance at rest was almost equal between the two groups, but in hypertensives the reduction during exercise was restricted. These results suggest that sympathetic activities of cardiovascular system are accentuated in juvenile hypertensive subjects.
对6名青少年高血压患者进行了研究,在连续超声心动图记录过程中让他们进行仰卧位自行车测力计运动。还对13名血压正常的年轻人进行了研究作为对照。运动期间,血压正常者的左心室舒张末期内径(Dd)从28.8±0.5mm/m²显著增加到29.7±0.6mm/m²,但高血压患者未观察到Dd增加。两组中普萘洛尔对运动期间Dd变化的影响几乎相同。两组运动期间左心室收缩末期内径(Ds)均减小。服用普萘洛尔后,高血压患者休息时的Ds从18.8±1.0mm/m²显著增加到19.4±1.1mm/m²,在随后的运动中达到19.7±1.1mm/m²,而血压正常者即使在服用普萘洛尔后运动期间Ds仍减小。两组静息时外周血管阻力几乎相同,但高血压患者运动期间的降低受到限制。这些结果表明青少年高血压患者心血管系统的交感神经活动增强。