Tanimoto M, Yamamoto T, Saito Y, Yasutomi N, Makihata S, Kimura S, Koide T, Kawai Y, Iwasaki T, Yorifuji S
J Cardiogr. 1981 Sep;11(3):813-24.
Echocardiographic study was performed on the mitral valve echogram in cases with clinical as well as experimental acute myocardial infarction (AMI). The echocardiograms were recorded in 88 patients with AMI within 7 days from the onset. In 8 patients (9%), and abnormal monophasic triangular diastolic pattern of the mitral valve was observed. Among them, 6 were examined within 12 hours after the onset and the remainder 2 within 24 hours. In all 8, markedly prolonged isovolumic relaxation time (IRT) was present. Mitral valve motion, IRT and peak negative dp/dt of the left ventricle were examined in 5 mongrel dogs following obstruction of the main left coronary artery, one of which was followed up for next 24 hours. Following coronary occlusion, the IRT progressively prolonged from the control value of 20 msec to 130 msec (15 min), 130 msec (30 min), 140 msec (1 hr), 150 msec (6 hr) and 150 msec (24 hr), respectively. The respective values of peak negative dp/dt were 2,000, 800, 840, 840, and 620 mmHg/sec. The possible explanation for these changes was the impaired active relaxation of the left ventricle, resulting in a delayed opening (or at least the lack of usual diastolic opening) of the mitral value, which gave an abortive E-point or a markedly delayed D point. We conclude that the diastolic monophasic triangular pattern of the mitral valve echogram in a reflection of the prolonged left ventricular isovolumic relaxation, and an index of impaired left ventricular diastolic relaxation.
对临床及实验性急性心肌梗死(AMI)患者的二尖瓣超声心动图进行了超声心动图研究。在发病7天内对88例AMI患者进行了超声心动图记录。8例患者(9%)观察到二尖瓣舒张期异常单相三角形模式。其中,6例在发病后12小时内接受检查,其余2例在24小时内接受检查。所有8例均存在明显延长的等容舒张时间(IRT)。对5只杂种犬在左冠状动脉主干阻塞后进行了二尖瓣运动、IRT和左心室最大负dp/dt检查,其中1只犬随访了接下来的24小时。冠状动脉闭塞后,IRT从对照值20毫秒分别逐渐延长至130毫秒(15分钟)、130毫秒(30分钟)、140毫秒(1小时)、150毫秒(6小时)和150毫秒(24小时)。最大负dp/dt的相应值分别为2000、800、840、840和620mmHg/秒。这些变化的可能解释是左心室主动舒张受损,导致二尖瓣延迟开放(或至少缺乏正常的舒张期开放),从而产生顿挫的E点或明显延迟的D点。我们得出结论,二尖瓣超声心动图舒张期单相三角形模式反映了左心室等容舒张时间延长,是左心室舒张功能受损的一个指标。