Ohte N, Nakano S, Mizutani Y, Samoto T, Fujinami T
J Cardiogr. 1986 Mar;16(1):115-20.
Left ventricular end-diastolic pressure (LVEDP) was estimated noninvasively using cardiac parameters obtained from simultaneous recordings of the echocardiograms, electrocardiograms and phonocardiograms in 30 patients who underwent diagnostic left cardiac catheterization. Special attention was paid to the mitral valve motion which reflects global left ventricular function. The interval from the onset of the Q wave of the ECG to the echocardiographic C point of mitral valve closure (Q-C), the interval from the aortic component of the second heart sound to the E point of the mitral echogram (IIa-E), and the time from the opening of the mitral valve (D point) to the E point (D-E) were measured. A good correlation with LVEDP was observed with Q-C/IIa-E (r = 0.87, p less than 0.001), and inversely with D-E time (r = -0.81, p less than 0.001). The correlation of Q-C/D-E and LVEDP was most significant (r = 0.89, p less than 0.001). The regression equations were LVEDP = 36.6 X (Q-C/IIa-E) -10.9 and LVEDP = 4.49 X (Q-C/D-E) +5.56. This noninvasive and easily repeated method for predicting LVEDP is very useful clinically.
在30例接受诊断性左心导管检查的患者中，利用同时记录的超声心动图、心电图和心音图所获得的心脏参数，对左心室舒张末期压力（LVEDP）进行了无创估计。特别关注反映左心室整体功能的二尖瓣运动。测量了心电图Q波起始至二尖瓣关闭的超声心动图C点的间期（Q-C）、第二心音主动脉成分至二尖瓣超声心动图E点的间期（IIa-E）以及二尖瓣开放（D点）至E点的时间（D-E）。观察到Q-C/IIa-E与LVEDP有良好的相关性（r = 0.87，p<0.001），而与D-E时间呈负相关（r = -0.81，p<0.001）。Q-C/D-E与LVEDP的相关性最为显著（r = 0.89，p<0.001）。回归方程为LVEDP = 36.6×（Q-C/IIa-E）-10.9和LVEDP = 4.49×（Q-C/D-E）+5.56。这种无创且易于重复的预测LVEDP的方法在临床上非常有用。
