Ramakrishnan R, Dell R B, Goodman D S
J Lipid Res. 1981 Nov;22(8):1174-80.
Whole body cholesterol turnover is well described by a three-pool model. This model has eight unknown parameters: three masses, three synthesis rates, and two intercompartmental exchange rates. Only six parameters can be estimated by fitting the model to the plasma specific radioactivity-time curve which results from the intravenous injection of labeled cholesterol. Additional information is obtained if a precursor of cholesterol, labeled with a different isotope, is also injected. Equations are derived to enable the calculation of all eight model parameters from the two sum-of-exponentials equations that are fitted to the two tracer curves. The characteristics of a satisfactory precursor are discussed.
全身胆固醇周转率可用三池模型很好地描述。该模型有八个未知参数：三个质量、三个合成速率和两个隔室间交换速率。通过将模型拟合至静脉注射标记胆固醇后得到的血浆比放射性-时间曲线，只能估计六个参数。如果还注射了用不同同位素标记的胆固醇前体，则可获得额外信息。推导了一些方程，以便能够从拟合两条示踪曲线的两个指数和方程计算出所有八个模型参数。讨论了理想前体的特征。
