Gazave J M, Pfister A, Toussaint M
J Mal Vasc. 1981;6(4):293-6.
Histamine chlorhydrate was intravenously injected to Guinea pigs (7 microgram/kg). Alterations of the alveolar walls capillaries were by electronic microscopy studied 1.5, 12 and 15 minutes after injection. It was observed a rapid dilator effect associated with an opening of the endothelial cells tight junctions, an increasing in the size and turnover of pinocytic vesicles, an enlargement and a loss of homogeneity of the basal membrane and an edema of type I pneumocytes. In the last group of animals, lesions reversibility is characterized by a beginning of closing of endothelial cells junctions and of edema resorption. These morphological findings point out the local effect of histamine on the pulmonary capillary microcirculation and show the decrease of resistance and the increase of permeability of the capillaries.
向豚鼠静脉注射盐酸组胺（7微克/千克）。注射后1.5、12和15分钟，通过电子显微镜研究肺泡壁毛细血管的变化。观察到一种快速的扩张效应，伴有内皮细胞紧密连接的开放、吞饮小泡大小和周转率的增加、基底膜的增大和均匀性丧失以及I型肺泡上皮细胞水肿。在最后一组动物中，病变的可逆性表现为内皮细胞连接开始闭合和水肿吸收。这些形态学发现指出了组胺对肺毛细血管微循环的局部作用，并显示了毛细血管阻力的降低和通透性的增加。
