• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Sodium efflux in rabbit myocardium: relationship to sodium-calcium exchange.兔心肌中的钠外流：与钠钙交换的关系。
J Physiol. 1981 Jul;316:555-74. doi: 10.1113/jphysiol.1981.sp013806.
2
Mechanisms contributing to the cardiac inotropic effect of Na pump inhibition and reduction of extracellular Na.钠泵抑制和细胞外钠减少导致心脏正性肌力作用的机制。
J Gen Physiol. 1987 Oct;90(4):479-504. doi: 10.1085/jgp.90.4.479.
3
Electromechanical studies on the inotropic effects of acetylstrophanthidin in ventricular muscle.乙酰毒毛旋花子苷对心室肌变力作用的机电研究。
J Physiol. 1975 Dec;253(2):357-84. doi: 10.1113/jphysiol.1975.sp011194.
4
Effects of hyperkalemia and glycoside on thallium exchange in rabbit ventricle.高钾血症和糖苷对兔心室铊交换的影响。
Am J Physiol. 1981 Apr;240(4):H612-9. doi: 10.1152/ajpheart.1981.240.4.H612.
5
Effect of acetylstrophanthidin on twitches, microscopic tension fluctuations and cooling contractures in rabbit ventricle.乙酰毒毛旋花子苷对兔心室肌收缩、显微张力波动及冷却挛缩的影响。
J Physiol. 1988 Oct;404:53-69. doi: 10.1113/jphysiol.1988.sp017278.
6
Effect of potassium depolarization on sodium-dependent calcium efflux from goldfish heart ventricles and guinea-pig atria.钾离子去极化对金鱼心室和豚鼠心房钠依赖性钙外流的影响。
J Physiol. 1982 Jun;327:309-24. doi: 10.1113/jphysiol.1982.sp014233.
7
The effects of caffeine on sodium transport, membrane potential, mechanical tension and ultrastructure in barnacle muscle fibres.咖啡因对藤壶肌纤维中钠转运、膜电位、机械张力和超微结构的影响。
J Physiol. 1974 Oct;242(1):1-34. doi: 10.1113/jphysiol.1974.sp010691.
8
Glycoside inotropy in the absence of an increase in potassium efflux in the rabbit heart.兔心脏中在钾外流不增加情况下的糖苷性变力作用。
Circ Res. 1975 Sep;37(3):390-5. doi: 10.1161/01.res.37.3.390.
9
Differential effects of ouabain and 2,4-dinitrophenol on contractile tension of and on sodium and calcium efflux from frog heart ventricular strips.哇巴因和2,4-二硝基苯酚对蛙心心室肌条收缩张力以及钠和钙外流的不同影响。
Br J Pharmacol. 1981 Oct;74(2):341-51. doi: 10.1111/j.1476-5381.1981.tb09977.x.
10
A constraint on possible stoichiometries of myocardial sodium-calcium exchange.心肌钠钙交换可能的化学计量比的限制因素。
Basic Res Cardiol. 1988 May-Jun;83(3):314-26. doi: 10.1007/BF01907365.

引用本文的文献

1
Excitation- and rest-dependent shifts of Ca in guinea-pig ventricular myocardium.豚鼠心室肌中钙的兴奋依赖性和静息依赖性移位
Pflugers Arch. 1983 Jul;398(2):103-13. doi: 10.1007/BF00581056.
2
A constraint on possible stoichiometries of myocardial sodium-calcium exchange.心肌钠钙交换可能的化学计量比的限制因素。
Basic Res Cardiol. 1988 May-Jun;83(3):314-26. doi: 10.1007/BF01907365.
3
Sodium/calcium exchange and intracellular calcium buffering in ferret myocardium: an ion-sensitive micro-electrode study.雪貂心肌中的钠/钙交换与细胞内钙缓冲：一项离子敏感微电极研究。
J Physiol. 1986 Apr;373:163-79. doi: 10.1113/jphysiol.1986.sp016040.

本文引用的文献

1
The resting exchange of radioactive potassium in crab nerve.蟹神经中放射性钾的静息交换
J Physiol. 1951 Mar;113(1):73-98. doi: 10.1113/jphysiol.1951.sp004557.
2
PERMEABILITY OF MAMMALIAN HEART CAPILLARIES TO SUCROSE AND INULIN.哺乳动物心脏毛细血管对蔗糖和菊粉的通透性
Am J Physiol. 1964 May;206:985-91. doi: 10.1152/ajplegacy.1964.206.5.985.
3
TRACER AND NON-TRACER POTASSIUM FLUXES IN FROG SARTORIUS MUSCLE AND THE KINETICS OF NET POTASSIUM MOVEMENT.蛙缝匠肌中示踪与非示踪钾离子通量及净钾离子移动动力学
J Gen Physiol. 1964 Mar;47(4):605-38. doi: 10.1085/jgp.47.4.605.
4
Changes in the sodium, potassium and chloride of rabbit auricles treated with ouabain.用哇巴因处理的兔耳廓中钠、钾和氯的变化。
J Physiol. 1962 Sep;163(2):347-61. doi: 10.1113/jphysiol.1962.sp006980.
5
The effect of sudden changes in ionic concentrations on the membrane potential of single muscle fibres.离子浓度突然变化对单根肌纤维膜电位的影响。
J Physiol. 1960 Sep;153(2):370-85. doi: 10.1113/jphysiol.1960.sp006540.
6
Chloride ions and the membrane potential of Purkinje fibres.氯离子与浦肯野纤维的膜电位
J Physiol. 1961 Apr;156(2):375-88. doi: 10.1113/jphysiol.1961.sp006682.
7
Intracellular recording from moving tissues with a flexibly mounted ultramicroelectrode.使用柔性安装的超微电极对移动组织进行细胞内记录。
Science. 1956 Jan 20;123(3186):100-1. doi: 10.1126/science.123.3186.100-a.
8
The electrical constants of Purkinje fibres.浦肯野纤维的电学常数。
J Physiol. 1952 Nov;118(3):348-60. doi: 10.1113/jphysiol.1952.sp004799.
9
Membrane capacity of the cardiac Purkinje fibre.心脏浦肯野纤维的膜容量。
J Physiol. 1966 Jan;182(2):255-67. doi: 10.1113/jphysiol.1966.sp007823.
10
The effect of cyanide on the efflux of calcium from squid axons.氰化物对鱿鱼轴突钙外流的影响。
J Physiol. 1969 Feb;200(2):497-527. doi: 10.1113/jphysiol.1969.sp008704.

兔心肌中的钠外流：与钠钙交换的关系。

Sodium efflux in rabbit myocardium: relationship to sodium-calcium exchange.

作者信息

Bridge J H, Cabeen W R, Langer G A, Reeder S

出版信息

J Physiol. 1981 Jul;316:555-74. doi: 10.1113/jphysiol.1981.sp013806.

DOI:10.1113/jphysiol.1981.sp013806
PMID:7320882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1248161/
Abstract
  1. The washout of (22)Na, (45)Ca and (58)CoEDTA(-) has been observed in arterially perfused rabbit interventricular septa both in the presence and absence of intoxicating doses of the aglycone, 3 acetylstrophanthidin (ACS).2. The washout of (22)Na from paced septa (21.0/min) was rapid with approximately 99% of the exchange occurring in 30 min.3. Septa labelled with (22)Na and washed out in the presence of 10(-5)m-ACS were quiescent, exhibited marked contracture and a slowed (22)Na exchange with 99% of the initial (22)Na leaving the tissue in approximately 200 min.4. Comparison of the washout of the extracellular marker (58)CoEDTA(-) from paced and intoxicated septa revealed no differences, suggesting that regions of the extracellular space had not become inexchangeable as a result of the contracture that these septa exhibited.5. Simultaneous measurements of the distribution of (22)Na and (58)CoEDTA(-) in the presence of 10(-5)m-ACS revealed an apparent cellular Na concentration of 54.8+/-10.4 (s.e.). This was considerably in excess of the maximum amount of Na contributing to the slowest component of Na efflux from intoxicated septa. Origins of this discrepancy are considered.6. The slowest component of (22)Na efflux from intoxicated septa could be markedly stimulated by increasing the external Ca concentration from a nominal 1.5 to 16 mm. The magnitude of stimulation was 44.3+/-7.8% (s.e.). Increases in the concentration of Mg from 1.0 to 16.0 mm were without effect on the (22)Na efflux.7. Application of 10(-5)m-ACS produced marked depolarization of the membrane to new stable levels that lay between -10 and -20 mV.8. Washout of ACS after several hours of intoxication resulted in a partial decline in contracture tension, an acceleration of Ca efflux, little change in (22)Na efflux and a repolarization of the cell membrane.9. Some of the Na and Ca movements reported in this paper have been interpreted by supposing that there is, in this preparation, a coupled exchange of three Na ions for a single Ca ion.
摘要

  1. 在使用和不使用中毒剂量的苷元3-乙酰毒毛旋花子苷元（ACS）的情况下，均观察到动脉灌注兔室间隔中（22）钠、（45）钙和（58）钴乙二胺四乙酸盐（-）的洗脱情况。

  2. 起搏间隔（每分钟21.0次）中（22）钠的洗脱很快，约99%的交换在30分钟内发生。

  3. 用（22）钠标记并在10^-5m-ACS存在下洗脱的间隔处于静止状态，表现出明显的挛缩，（22）钠交换减慢，约99%的初始（22）钠在约200分钟内离开组织。

  4. 对起搏和中毒间隔中细胞外标记物（58）钴乙二胺四乙酸盐（-）的洗脱进行比较，未发现差异，这表明细胞外空间区域并未因这些间隔所表现出的挛缩而变得不可交换。

  5. 在10^-5m-ACS存在下同时测量（22）钠和（58）钴乙二胺四乙酸盐（-）的分布，显示细胞内钠浓度明显为54.8±10.4（标准误）。这大大超过了导致中毒间隔中钠外流最慢成分的最大钠量。文中考虑了这种差异的来源。

  6. 将中毒间隔中（22）钠外流的最慢成分显著刺激的方法是将外部钙浓度从名义上的1.5毫米增加到16毫米。刺激幅度为44.3±7.8%（标准误）。将镁浓度从1.0毫米增加到16.0毫米对（22）钠外流没有影响。

  7. 应用10^-5m-ACS使膜明显去极化至-10至-20毫伏之间的新稳定水平。

  8. 中毒数小时后洗脱ACS导致挛缩张力部分下降、钙外流加速、（22）钠外流变化不大以及细胞膜复极化。

  9. 本文报道的一些钠和钙的移动情况被解释为，在此制剂中，存在三个钠离子与一个钙离子的耦合交换。