Tran M A, Géral J P
Eur J Pharmacol. 1978 Nov 1;52(1):109-14. doi: 10.1016/0014-2999(78)90027-4.
We have studied the effect of various drugs on the intramedullary pressure in dog tibia after constant-flow autoperfusion of the nutrient artery by femoral arterial blood. The perfusion pressure and carotid arterial pressure were also recorded. Isoprenaline, acetylcholine, histamine, theophylline always lowered the perfusion pressure but had a variable effect on intramedullary pressure. This results from several factors e.g., perfusion pressure and intraosseous vasomotoricity. Adrenaline always caused a rise of the perfusion pressure and lowered the intramedullary pressure in most of the cases. Such effects were reduced or suppressed by alpha-blocking drugs. Isoprenaline caused a lowering of the perfusion pressure which was suppressed by propranolol. A rise of the intramedullary pressure through beta-induced vasodilatation was shown in some experiments. The effect of adrenaline on the perfusion pressure could be reversed after alpha-blockade. These results show the presence of intraosseous vascular alpha- and beta-adrenoceptors.
我们通过股动脉血恒流自动灌注狗胫骨的营养动脉，研究了各种药物对狗胫骨骨髓内压力的影响。同时记录了灌注压力和颈动脉压力。异丙肾上腺素、乙酰胆碱、组胺、茶碱总是降低灌注压力，但对骨髓内压力的影响各不相同。这是由多种因素造成的，例如灌注压力和骨内血管运动性。肾上腺素总是导致灌注压力升高，并且在大多数情况下降低骨髓内压力。α受体阻断药可减弱或抑制这种作用。异丙肾上腺素导致灌注压力降低，而普萘洛尔可抑制这种降低。在一些实验中显示，通过β受体诱导的血管舒张可使骨髓内压力升高。α受体阻断后，肾上腺素对灌注压力的作用可被逆转。这些结果表明骨内血管存在α和β肾上腺素能受体。
