Bouillé C, Layton B, Renaud L P
Neuroendocrinology. 1981 Dec;33(6):321-7. doi: 10.1159/000123255.
Extracellular recordings from medial hypothalamic neurons in pentobarbital-anesthetized male Sprague-Dawley rats were evaluated during electrical stimulation in the ipsilateral and contralateral dorsal hippocampus/fimbria region. Similar short latency orthodromic (excitatory or inhibitory) responses were noted from both ipsilateral and contralateral stimulation sites indicating a bilateral projection. 14.5% of neurons responded to both stimuli, usually with a similar pattern of response. When neurons were also tested with ipsilateral basal or corticomedial amygdala stimulation, 21.5-22.8% of cells displayed orthodromic responses to both the hippocampus and the amygdala stimulus. 12.5% of medial hypothalamic tuberoinfundibular neurons also responded orthodromically to the hippocampal stimulus; a preceding stimulus to the amygdala could block this response in two of three tuberoinfundibular cells. These observations provide preliminary electrophysiological analysis of the functional connectivity of hippocampal and amygdala afferents to medial hypothalamic neurons that may underlie the influence of these extrahypothalamic regions on adenohypophyseal secretions.
在戊巴比妥麻醉的雄性Sprague-Dawley大鼠中，对内侧下丘脑神经元进行细胞外记录，记录过程中对同侧和对侧背侧海马/穹窿区进行电刺激。同侧和对侧刺激部位均记录到类似的短潜伏期顺行性（兴奋性或抑制性）反应，表明存在双侧投射。14.5%的神经元对两种刺激均有反应，通常反应模式相似。当也用同侧基底或皮质内侧杏仁核刺激对神经元进行测试时，21.5%-22.8%的细胞对海马和杏仁核刺激均表现出顺行性反应。12.5%的内侧下丘脑结节漏斗神经元对海马刺激也有顺行性反应；在三个结节漏斗细胞中的两个细胞中，先前对杏仁核的刺激可阻断这种反应。这些观察结果为海马和杏仁核传入内侧下丘脑神经元的功能连接提供了初步的电生理分析，这可能是这些下丘脑外区域对腺垂体分泌产生影响的基础。
