Sole M J, Shum A, Adams D, Lixfeld W
Neurosci Lett. 1981 Dec 11;27(2):183-6. doi: 10.1016/0304-3940(81)90265-2.
Serotonin synthesis, as estimated by the accumulation of 5-hydroxytryptophan 25 min following aromatic-L-amino acid decarboxylase inhibition, was measured in the medulla, pons-midbrain and posterior and anterior hypothalamus of rats subjected to left coronary artery ligation and their sham-operated controls. Left coronary artery ligation led to reduction in the rate of serotonin synthesis in the medulla and posterior hypothalamus. The topical administration of lidocaine to the left ventricle or vagotomy completely obviated these occlusion-induced changes. We conclude that there is an inhibition of serotonergic activity in the medulla and posterior hypothalamus after left coronary artery occlusion in the rat. The afferent signal arises from receptors in the ischemic left ventricle and is conducted by the vagus.
通过抑制芳香族L-氨基酸脱羧酶25分钟后5-羟色氨酸的积累来估计血清素合成，在接受左冠状动脉结扎的大鼠及其假手术对照的延髓、脑桥-中脑以及下丘脑后部和前部进行了测量。左冠状动脉结扎导致延髓和下丘脑后部血清素合成速率降低。向左心室局部注射利多卡因或切断迷走神经完全消除了这些闭塞引起的变化。我们得出结论，大鼠左冠状动脉闭塞后，延髓和下丘脑后部的血清素能活性受到抑制。传入信号来自缺血左心室中的受体，并通过迷走神经传导。
