Smith M L, Browning R A, Myers J H
Eur J Pharmacol. 1979 Jan 15;53(3):301-5. doi: 10.1016/0014-2999(79)90137-7.
The accumulation of 5-hydroxytryptophan (5-HTP) following decarboxylase inhibition was measured in hypothalamus (HYP), pons-medulla (PM) and spinal cord (SC) of 4- and 8-week-old spontaneously hypertensive (SH) and normotensive (WKY) rats. Using this method, a significant increase in the in vivo activity of tryptophan hydroxylase was observed in the PM and SC of 4-week-old, but not 8-week-old SH rats. These findings show a transient elevation in rate of 5-HT synthesis prior to the onset of hypertension, which does not appear to continue during the maintenance phase.
在4周龄和8周龄的自发性高血压（SH）大鼠和正常血压（WKY）大鼠的下丘脑（HYP）、脑桥延髓（PM）和脊髓（SC）中，测量了脱羧酶抑制后5-羟色氨酸（5-HTP）的积累情况。采用这种方法，在4周龄而非8周龄的SH大鼠的PM和SC中，观察到色氨酸羟化酶的体内活性显著增加。这些发现表明，在高血压发作之前5-羟色胺合成速率有短暂升高，但在维持阶段似乎并未持续。
