Condes-Lara Miguel, Calvo Jose M, Fernandez-Guardiola Augusto
Unidad de Investigaciones Cerebrales, Instituto Nacional de Neurología y Neurocirugía and Facultad de Psicología, Universidad Nacional Autónoma de México, Mexico Mexico.
Pain. 1981 Oct;11(2):185-200. doi: 10.1016/0304-3959(81)90004-X.
Stimulation (1/10 sec, 1-2 msec) of the tooth pulp of volunteers was carried out for 120 min at an intensity that produced bearable pain. Cortical evoked potentials, electroencephalographic activity, electromyograms of the superciliary and masseter muscles and galvanic skin response were recorded. Every 30 min, without suspending the stimulation, the subjects were questioned with respect to the sensations accompanying the stimuli. A progressive decrease in all polygraphic responses was observed which coincided with a decrease in the reported sensation of pain. This effect could be reversed by applying heterosensorial stimulation (questioning). It is suggested that this is a phenomenon of habituation to pain since dishabituation, potentiation of habituation, and habituation to dishabituation were found.
对志愿者的牙髓进行刺激（1/10秒，1 - 2毫秒），以产生可耐受疼痛的强度持续刺激120分钟。记录皮层诱发电位、脑电图活动、眉肌和咬肌的肌电图以及皮肤电反应。每30分钟，在不中断刺激的情况下，询问受试者与刺激相关的感觉。观察到所有多导记录反应逐渐下降，这与报告的疼痛感觉下降相一致。通过施加异感觉刺激（询问）可以逆转这种效应。由于发现了去习惯化、习惯化的增强以及对去习惯化的习惯化，因此认为这是一种对疼痛的习惯化现象。
