Van Ameringen M R, Fouron J C, Bard H, Le Guennec J C, Prosmanne J
Pediatr Res. 1981 Dec;15(12):1500-3. doi: 10.1203/00006450-198112000-00009.
Experiments to determine the effect of the oxygen-hemoglobin dissociation curve on oxygen delivery during neonatal anemia, were carried out on 15 sedated and ventilated lambs less than 48 hr of age. Eight of the animals were exchange transfused with adult blood. The P50 of the exchange transfused group was 32.1 mm Hg (low O2 affinity) compared to 19.4 mm Hg for the controls (high O2 affinity). The animals were made anemic by isovolumic exchange transfusions with plasma. At different levels of hemoglobulin defined as mild (8 mg/100 ml), moderate (6 mg/100 ml), and severe (4 mg/100 ml) anemia, tissue oxygenation, hemodynamic status, and blood gases were compared. Mixed venous PO2 was significantly lower in the high affinity group throughout this study. Cardiac output was significantly greater in the low affinity group during severe anemia. Oxygen consumption remained stable in the low affinity group, but decreased significantly in the high affinity group when the anemia was severe. The data indicate that during severe anemia, blood with a high P50 is more capable of adequately oxygenating tissues than that with a low P50.
为了确定新生儿贫血期间氧-血红蛋白解离曲线对氧输送的影响，对15只年龄小于48小时、处于镇静和机械通气状态的羔羊进行了实验。其中8只动物接受了成人血液的换血治疗。换血治疗组的P50为32.1毫米汞柱（低氧亲和力），而对照组为19.4毫米汞柱（高氧亲和力）。通过用血浆进行等容换血使动物贫血。在定义为轻度（8毫克/100毫升）、中度（6毫克/100毫升）和重度（4毫克/100毫升）贫血的不同血红蛋白水平下，比较了组织氧合、血流动力学状态和血气。在整个研究过程中，高亲和力组的混合静脉血氧分压显著更低。在重度贫血期间，低亲和力组的心输出量显著更高。低亲和力组的氧消耗保持稳定，但在重度贫血时高亲和力组的氧消耗显著下降。数据表明，在重度贫血期间，P50高的血液比P50低的血液更能充分地使组织氧合。
