Alemi B, Hamosh M, Scanlon J W, Salzman-Mann C, Hamosh P
Pediatrics. 1981 Oct;68(4):484-9.
The possible compensatory role of human milk lipase in the digestion of dietary fat was examined in a group of very low-birth-weight infants. Fat excretion was studied in 15 preterm infants of gestational age 26 to 33 weeks and birth weight 660 to 1,695 gm. The amount and composition of fecal fat were determined in stools collected for 72 hours. Eight infants were fed Similac 24 LBW exclusively and seven infants were fed a mixture of fresh human milk (40%) and formula (60%). Fat excretion was lower in infants fed a mixture of human milk and formula than in infants fed formula only (4.7% -+/- 0.50% vs 11.9% +/- 1.4% of intake, respectively). Excretion of calcium soaps, when expressed as percent of total fat, was higher in the group fed the human milk-containing diet (18.9% +/- 13.5%), than in the group fed formula only (6.8 +/- 2.5%); however, the absolute amounts excreted were similar in both groups (65 +/- 46 and 45 +/- 17 mg/kg/day, respectively). The lower fat excretion in infants fed a mixture of fresh human milk and formula could be related to the lipase present in human milk. These data suggest that human milk lipase probably contributes to the digestion and absorption of dietary fat in the "tiny premature" infant.
在一组极低出生体重儿中研究了人乳脂肪酶在膳食脂肪消化中可能的代偿作用。对15名胎龄26至33周、出生体重660至1695克的早产儿的脂肪排泄情况进行了研究。收集72小时的粪便，测定其中粪便脂肪的量和成分。8名婴儿仅喂食Similac 24 LBW，7名婴儿喂食新鲜人乳（40%）和配方奶（60%）的混合物。喂食人乳和配方奶混合物的婴儿脂肪排泄量低于仅喂食配方奶的婴儿（分别为摄入量的4.7%±0.50%和11.9%±1.4%）。以总脂肪百分比表示时，喂食含人乳饮食组的钙皂排泄量（18.9%±13.5%）高于仅喂食配方奶组（6.8±2.5%）；然而，两组排泄的绝对量相似（分别为65±46和45±17毫克/千克/天）。喂食新鲜人乳和配方奶混合物的婴儿脂肪排泄量较低可能与人乳中存在的脂肪酶有关。这些数据表明，人乳脂肪酶可能有助于“极小早产儿”对膳食脂肪的消化和吸收。
