Stern P, LaRochelle F T, Little G A
Pediatrics. 1981 Oct;68(4):499-503.
The release of vasopressin (AVP) was assessed by measuring urinary excretion of the hormone in ten neonates who had an acute and symptomatic pneumothorax in the first three days after birth. AVP excretion rose significantly (paired t analysis) after the pneumothorax occurred. When apparent re-expansion of the lungs occurred after treatment, excretion of AVP returned to prepneumothorax levels within eight to 16 hours. If the pneumothorax persisted or worsened. AVP excretion remained elevated. Urine osmolality rose significantly (paired t analysis) after pneumothorax, presumably in response to the increased AVP levels. Two of the ten infants had hyponatremia in the period studied, while in a state of sodium balance. It was concluded that AVP release is increased after a pneumothorax occurs. This increase is apparently not due to osmoregulatory requirements. Fluid intake in these infants may need adjustment to prevent an inappropriate positive water balance.
通过测量10名出生后三天内患有急性症状性气胸的新生儿尿液中抗利尿激素（AVP）的排泄量，来评估AVP的释放情况。气胸发生后，AVP排泄量显著上升（配对t检验）。治疗后肺部明显复张时，AVP排泄量在8至16小时内恢复到气胸前水平。如果气胸持续或恶化，AVP排泄量仍会升高。气胸后尿渗透压显著上升（配对t检验），这可能是对AVP水平升高的反应。在研究期间，10名婴儿中有两名处于钠平衡状态时出现低钠血症。得出的结论是，气胸发生后AVP释放增加。这种增加显然不是由于渗透压调节需求。可能需要调整这些婴儿的液体摄入量，以防止不适当的正水平衡。
